Biochem/physiol Actions

Target IC₅₀: 78 µM against Janus family kinase 3

Reversible: yes

Product competes with ATP.

Primary TargetJanus family kinase 3

Cell permeable: yes

General description

A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC₅₀ = 78 µM). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases. Blocks thrombin-induced platelet aggregation.

A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC₅₀ = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Tibbles, H.E., et al. 2001. J. Biol. Chem.276, 17815.Sudbeck, E.A., et al. 1999. Clin. Cancer Res.5, 1569.Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)